I'm in the same boat, I didn't do anything to the New Twiddler4, just playing around with it, F1R2R3R4R works but as soon as I did the F1M2M3M4M now stuck in Num Lock can't seem to get out of it.
Edit: It is back to normal, all I did was plug in my USB cable, nothing happened and I could not get a response from the T4. Unplugged it and now back to normal.